姓名

鐘根深

職稱

教授

學位

博士

郵箱

genshenzhong@163.com

教育經曆

2015.03-2016.02美國賓夕法尼亞大學，博士後；導師：Powell DJ Jr

2007.09-2010.07北京協和醫學院，微生物與生化藥學，博士；

2003.09-2006.07軍事醫學科學院，病理學與病理生理學，碩士；

1999.09-2003.07山東大學，生物技術專業，學士

科研項目

1.湖南省自然科學基金,面上基金, 2023JJ30091,過表達ATPIF1降低靶向Her-2 CAR-T細胞抗腫瘤功能的機制研究，2023/01-2025/12,在研,主持；

2.國家自然科學基金，聯合基金，U1904131，ATPIF1調控T細胞代謝影響抗腫瘤免疫的實驗研究，2020.01-2022.12，已結題，主持；

3.國家自然科學基金，青年基金，81201765，抗明膠酶scFv-LDM雙價融合蛋白的分子及其抗胰腺癌實驗研究，2013.01-2015.12，已結題，主持。

著作論文

1.Tao J, An Y, Xu L, Wang Y, Wang C, Li P, Li M, Yan D, Wang M,Zhong G*, Wu M*. The protective role of microbiota in the prevention of MPTP/P-induced Parkinson's disease by resveratrol. Food Funct; 2023; 14(10):4647-4661. doi: 10.1039/d2fo03379h.

2.Zhong G^#, Wang Q^#, Wang Y, Guo Y, Xu M, Guan Y, Zhang X, Wu M, Xu Z, Zhao W, Lian H, Wang H, Ye J*. scRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity, OncoImmunology, 2022; 11:1, 2114740, DOI: 10.1080/2162402X.2022.2114740.

3.Ren J, Yan D, Wang Y, Zhang J, Li M, Xiong W, Jing X, Li P, Zhao W, Xiong X, Wu M*,Zhong G*. Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-κB Activation in Neutrophils. Front Immunol, 2021; 12:760999. doi: 10.3389/fimmu.2021.760999.

4.Zhong G^*#, Wang Y^#, Wang Q, Wu M, Liu Y, Sun S, Li Z, Hao J, Dou P, Lin B*. Discovery of novel ID2 antagonists from pharmacophore-based virtual screening as potential therapeutics for glioma. Bioorg Med Chem, 2021; 49:116427. doi: 10.1016/j.bmc.2021.116427.

5.Zhong G^#, Zhang J^#, Guo Y, Wang Y, Wu M, Ren J, Li Y, Zhang X, Zhou B, Zhao W, Lou Y, Wang H*, Ye J*. IF1 inactivation attenuates experimental colitis through downregulation of neutrophil infiltration in colon mucosa. Int Immunopharmacol, 2021; 99:107980. doi: 10.1016/j.intimp.2021.107980

6.Wu M，Li P，An Y，Ren J，Yan D, Cui J，Li D, Li M, Wang M，Zhong G*. Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota. Pharmacol Res, 2019; doi.org/10.1016/j.phrs.2019.104489

7.Wu M, Li J, An Y, Li P, Xiong W, Li J, Yan D, Wang M,Zhong G*. Chitooligosaccharides Prevents the Development of Colitis-Associated Colorectal Cancer by Modulating the Intestinal Microbiota and Mycobiota. Front Microbiol, 2019; 10: 2101. doi: 10.3389/fmicb.2019.02101

8.Zhong G*, Xu Z, Yang R, Zhang S, Li L, Wu M, Liu H, Zhen Y. An arginine-rich cell penetrating peptide contained anti-gelatinase scFv-LDM fusion protein shows potent antitumor efficacy in pancreatic cancer. J Cancer, 2018; 9(4):674-682.

重要獎項

鐘根深2/5，旨在增強力達黴素抗腫瘤活性的靶向性融合蛋白的構建及活性檢測，河南省人民政府，省級，河南省自然科學三等獎，2019，證書編号：2019-Z-021-R02/05。

鐘根深3/10，腫瘤幹細胞标記CD133在結直腸癌中的作用及機制，河南省醫學會，廳級，河南醫學科技獎二等獎，2020，證書編号：2020-YJ-126-R03/10。